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. 1979 Jul-Aug;4(4):310-9.
doi: 10.2165/00003088-197904040-00004.

Pharmacokinetics of N1-acetyl- and N4-acetylsulphamethoxazole in man

T B Vree, Y A Hekster, J E Damsma, E van der Kleijn, W J O'Reilly

Pharmacokinetics of N1-acetyl- and N4-acetylsulphamethoxazole in man

T B Vree et al. Clin Pharmacokinet. 1979 Jul-Aug.

Abstract

The pharmacokinetics of N1-acetylsulphamethoxazole and N4-acetylsulphamethoxazole in man are described. N1-Acetylsulphamethoxazole is deacetylated to sulphamethoxazole and acetylated to N4-acetylsulphamethoxazole. N4-Acetylsulphamethoxazole is excreted almost unchanged in the urine. The renal excretion rate is independent of the urine flow and urinary pH. N4-Acetylsulphonamides are less lipid soluble and more acidic than their corresponding parent sulphonamides.

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