doi: 10.1002/cpt1979264508.
Tobramycin pharmacokinetics in morbidly obese patients
- PMID: 487698
- DOI: 10.1002/cpt1979264508
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Tobramycin pharmacokinetics in morbidly obese patients
Clin Pharmacol Ther.
1979 Oct.
Abstract
Tobramycin kinetics were examined in 9 morbidly obese women following a single intravenous (120 mg) bolus. After the injection, serum elimination conformed to a 2-compartment open model with alpha and beta t1/2s of 0.285 and 2.1 hr. The volume of distribution (Varea) was determined to be 0.44 1/kg ideal body weight (IBW) and 0.20 1/kg total body weight (TBW). To normalize Varea to 0.26 1/kg, 58% of the patients' adipose weight (TBW -- IBW) must also be taken into account.
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