doi: 10.1111/j.1432-1033.1979.tb13231.x.
A rare genetically determined variant of psuedocholinesterase in two German families with high plasma enzyme activity
- PMID: 488119
- DOI: 10.1111/j.1432-1033.1979.tb13231.x
Item in Clipboard
A rare genetically determined variant of psuedocholinesterase in two German families with high plasma enzyme activity
Eur J Biochem.
.
Free article
Abstract
Activity of pseudocholinesterase (acylcholine-acyl-hydrolase) elevated up to four times has been detected in sera of members of two German families. The catalytic concentrations of the pseudocholinesterase of the afflicted members of both families (male and female) varied between 4800 U/l and 10 200 U/o (acetylthiocholine iodide substrate). The pseudocholinesterase of the propositi exhibits isoenzyme separation patterns in polyacrylamide electrophoresis as well as in electrofocussing which are different from those of pseudocholinesterase from normal persons. No differences could be seen as regards the Km of substrates or the inhibition by dibucaine, fluoride or succinyldiocholine.
Similar articles
-
Serum atypical pseudocholinesterase and leprosy.Int J Dermatol. 1979 Dec;18(10):822-3. doi: 10.1111/j.1365-4362.1979.tb04474.x. Int J Dermatol. 1979. PMID: 528104
-
Pseudocholinesterase variation.Hum Genet Suppl. 1978;(1):45-55. doi: 10.1007/978-3-642-67179-1_7. Hum Genet Suppl. 1978. PMID: 285032 No abstract available.
-
Plasma cholinesterase: gene and variations.Anesth Analg. 1993 Aug;77(2):380-6. doi: 10.1213/00000539-199377020-00027. Anesth Analg. 1993. PMID: 8346840 Review.
-
Serum cholinesterase (pseudocholinesterase) in Down's syndrome: 1. Phenotype frequencies at the E1 and E2 loci.J Ment Defic Res. 1977 Sep;21(3):181-9. doi: 10.1111/j.1365-2788.1977.tb00037.x. J Ment Defic Res. 1977. PMID: 144799
-
GENETICAL VARIANTS OF HUMAN SERUM PSEUDOCHOLINESTERASE.Prog Med Genet. 1964;23:75-105. Prog Med Genet. 1964. PMID: 14110078 Review. No abstract available.
Cited by
-
Characterization of serum cholinesterase in familial hyper-cholinesterasemia associated with an isozyme variant band.Gastroenterol Jpn. 1987 Apr;22(2):187-93. doi: 10.1007/BF02774216. Gastroenterol Jpn. 1987. PMID: 3596154
-
A new high activity plasma cholinesterase variant.J Med Genet. 1988 Oct;25(10):677-81. doi: 10.1136/jmg.25.10.677. J Med Genet. 1988. PMID: 3225823 Free PMC article.
-
A case of familial hyper-cholinesterasemia associated with isozyme variant band.Gastroenterol Jpn. 1986 Aug;21(4):379-84. doi: 10.1007/BF02774136. Gastroenterol Jpn. 1986. PMID: 3770357
-
Proposed nomenclature for human butyrylcholinesterase genetic variants identified by DNA sequencing.Cell Mol Neurobiol. 1991 Feb;11(1):79-89. doi: 10.1007/BF00712801. Cell Mol Neurobiol. 1991. PMID: 2013061 Free PMC article.
-
Shortened action of succinylcholine in individuals with cholinesterase C5 isozyme.Can Anaesth Soc J. 1986 May;33(3 Pt 1):321-7. doi: 10.1007/BF03010744. Can Anaesth Soc J. 1986. PMID: 3719432
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
