The localization of [3H]-desipramine in central nerve terminals studied with electron microscope autoradiography and subcellular fractionation
- PMID: 488282
- DOI: 10.1007/BF01963295
The localization of [3H]-desipramine in central nerve terminals studied with electron microscope autoradiography and subcellular fractionation
Abstract
The cellular and subcellular distribution of [3H]-desipramine (DMI) in rat brain was studied by electron microscope (EM) autoradiography and by subcellular fractionation. A considerable proportion of label was found to be bound to the membranes of presynaptic nerve terminals, as well as to sites inside those terminals.
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