Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1968 Nov;2(11):1308-14.
doi: 10.1128/JVI.2.11.1308-1314.1968.

Host cell participation in small virus replication. I. Replication of M-13 in a strain of Escherichia coli with a temperature-sensitive lesion in deoxyribonucleic acid synthesis

S B Primrose, L R Brown, C E Dowell

Host cell participation in small virus replication. I. Replication of M-13 in a strain of Escherichia coli with a temperature-sensitive lesion in deoxyribonucleic acid synthesis

S B Primrose et al. J Virol. 1968 Nov.

Abstract

The replication of M-13 in a strain of Escherichia coli with a thermosensitive lesion in deoxyribonucleic acid synthesis was studied. M-13 failed to replicate at the restrictive temperature, even when the parental replicative form was allowed to form at the permissive temperature. When cells which were actively producing phage at the permissive temperature were shifted to the restrictive temperature, phage production continued. The incorporation of radioactive label into phage particles at 42 C indicated that continued single-strand synthesis was unaffected by the lesion in the host cell.

PubMed Disclaimer

References

    1. Virology. 1964 Nov;24:372-80 - PubMed
    1. Z Naturforsch B. 1963 Nov;18:893-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1968 Mar;59(3):911-6 - PubMed
    1. Virology. 1966 Nov;30(3):397-410 - PubMed
    1. Proc Natl Acad Sci U S A. 1967 Oct;58(4):1723-30 - PubMed

LinkOut - more resources