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. 1968 Sep;3(7):665-9.

Elution of antinuclear factor from renal lesions of NZB-NZW mice

A R McGiven, P N Ironside

Elution of antinuclear factor from renal lesions of NZB-NZW mice

A R McGiven et al. Clin Exp Immunol. 1968 Sep.

Abstract

Immunoglobulins could be eluted from the glomerular lesions of adult NZB/NZW mice by treatment with acid citrate buffer (pH 3·4). Antinuclear activity was detected in the eluates obtained from homogenates of the kidneys of four out of six mice and from one of two glomerular preparations from two other mice. It is suggested that ANF, as a component of circulating antigen–antibody complexes trapped in the glomeruli, may play a pathogenic role in the development of the glomerular lesions of NZB/NZW mice.

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