Human C'3: evidence for the liver as the primary site of synthesis
- PMID: 4883617
- DOI: 10.1126/science.163.3864.286
Human C'3: evidence for the liver as the primary site of synthesis
Abstract
The liver is the primary, if not sole, site of synthesis of the third component of human complement, as shown by a change in the recipient from C'3 FS(0.6) to C'3 SS, the donor type, following homotransplantation of the liver.
Similar articles
-
In vivo metabolism of complement. I. Metabolism of the third component (C'3) in acquired hemolytic anemia.J Clin Invest. 1969 Nov;47(11):2469-84. doi: 10.1172/JCI105929. J Clin Invest. 1969. PMID: 4975569 Free PMC article.
-
C'3 synthesis in the human fetus and lack of transplacental passage.Science. 1968 Nov 8;162(3854):672-3. doi: 10.1126/science.162.3854.672. Science. 1968. PMID: 4177644
-
Alper CA, Rosen FS: Studies of the in vivo behavior of human C'3 in normal subjects and patients.J Clin Invest. 1967 Dec;46(12):2021-34. doi: 10.1172/JCI105691. J Clin Invest. 1967. PMID: 6074005 Free PMC article.
-
Human complementary component C'3: an appraisal.Hum Genet. 1976 Aug 30;33(3):201-11. doi: 10.1007/BF00286844. Hum Genet. 1976. PMID: 786850 Review.
-
[Liver transplantation in humans].Schweiz Med Wochenschr. 1970 Jan 31;100(5):238-9. Schweiz Med Wochenschr. 1970. PMID: 4946439 Review. German. No abstract available.
Cited by
-
Peroxisome proliferator-activated receptor α positively regulates complement C3 expression but inhibits tumor necrosis factor α-mediated activation of C3 gene in mammalian hepatic-derived cells.J Biol Chem. 2013 Jan 18;288(3):1726-38. doi: 10.1074/jbc.M112.437525. Epub 2012 Nov 20. J Biol Chem. 2013. PMID: 23168409 Free PMC article.
-
Deficiency of serum bactericidal activity against Salmonella typhimurium in sickle cell anaemia.Clin Exp Immunol. 1977 Nov;30(2):262-70. Clin Exp Immunol. 1977. PMID: 342154 Free PMC article.
-
Intraglomerular C3 synthesis in rats with passive Heymann nephritis.Am J Pathol. 1997 Nov;151(5):1249-56. Am J Pathol. 1997. PMID: 9358750 Free PMC article.
-
Cellular specificity of murine renal C3 expression in two models of inflammation.Immunology. 1994 Apr;81(4):655-60. Immunology. 1994. PMID: 8039815 Free PMC article.
-
Transgenic Expression of the Anti-parasitic Factor TEP1 in the Malaria Mosquito Anopheles gambiae.PLoS Pathog. 2017 Jan 17;13(1):e1006113. doi: 10.1371/journal.ppat.1006113. eCollection 2017 Jan. PLoS Pathog. 2017. PMID: 28095489 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous