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. 1969 Mar 1;129(3):585-90.
doi: 10.1084/jem.129.3.585.

The role of the platelet in the generalized Shwartzman reaction

W Margaretten, D G McKay

The role of the platelet in the generalized Shwartzman reaction

W Margaretten et al. J Exp Med. .

Abstract

Rabbits were injected with an antiplatelet serum to produce selective thrombocytopenia without inducing a significant alteration of their leukocyte counts. Thrombocytopenic levels persisted for 8 hr after the injection of platelet antiserum. During this time, the generalized Shwartzman reaction could not be provoked with the second injection of endotoxin. Since platelet phospholipid is required for the formation of plasma thromboplastin, the results indicate that platelets are essential to the evolution of the generalized Shwartzman reaction and endotoxin triggers the intrinsic rather than the extrinsic clotting system to elicit the lesions.

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References

    1. J Exp Med. 1965 Feb 1;121:235-46 - PubMed
    1. J Exp Med. 1953 Jun;97(6):871-88 - PubMed
    1. J Exp Med. 1963 Mar 1;117:365-76 - PubMed
    1. J Exp Med. 1962 Nov 1;116:619-33 - PubMed
    1. J Exp Med. 1952 Dec;96(6):605-24 - PubMed