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. 1969 Feb;97(2):848-60.
doi: 10.1128/jb.97.2.848-860.1969.

Chromosome replication in Salmonella typhimurium

H Chan, K G Lark

Chromosome replication in Salmonella typhimurium

H Chan et al. J Bacteriol. 1969 Feb.

Abstract

The replication of the Salmonella typhimurium chromosome was studied. As with E. coli 15T(-), replication was sequential. After amino acid starvation, replication proceeded from a unique and heritable region of the chromosome. 5-Bromouracil, when substituted for thymine, did not disturb the sequence of replication nor did it initiate extra replication cycles. By labeling the origin and the terminus of the chromosome with (3)H- and (14)C-thymine, respectively, it was possible to determine that the rate of chain elongation decreases as the growth rate decreases. No gap in the replication cycle could be observed.

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References

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