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. 1967 Apr 21;156(3773):402-3.
doi: 10.1126/science.156.3773.402.

Serotonin: release in the forebrain by stimulation of midbrain raphé

Serotonin: release in the forebrain by stimulation of midbrain raphé

G K Aghajanian et al. Science. .

Abstract

Electrical stimulation of the midbrain raphé, an area in which neuronal perikarya containing serotonin are aggregated, produces an increase in 5-hydroxyindoleacetic acid and a decrease in serotonin in the forebrain. These changes indicate that serotonin in the brain can be released via a specific neural pathway, namely, the system of axons projecting into the forebrain from serotonin-containing neurons in the midbrain raphé.

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