Serotonin: release in the forebrain by stimulation of midbrain raphé
- PMID: 4886538
- DOI: 10.1126/science.156.3773.402
Serotonin: release in the forebrain by stimulation of midbrain raphé
Abstract
Electrical stimulation of the midbrain raphé, an area in which neuronal perikarya containing serotonin are aggregated, produces an increase in 5-hydroxyindoleacetic acid and a decrease in serotonin in the forebrain. These changes indicate that serotonin in the brain can be released via a specific neural pathway, namely, the system of axons projecting into the forebrain from serotonin-containing neurons in the midbrain raphé.
Similar articles
-
Effect of stimulation of midbrain raphe on serotonin (5-HT) level and turnover in different areas of rat brain.Eur J Pharmacol. 1969 Dec;8(3):380-4. doi: 10.1016/0014-2999(69)90051-x. Eur J Pharmacol. 1969. PMID: 5370238 No abstract available.
-
Some factors influencing the release of 5-hydroxyindol-3-ylacetic acid in the forebrain.Br J Pharmacol. 1970 May;39(1):1-8. doi: 10.1111/j.1476-5381.1970.tb09550.x. Br J Pharmacol. 1970. PMID: 5420100 Free PMC article.
-
Stimulation of the midbrain raphe: effect on serotonin metabolism.J Pharmacol Exp Ther. 1968 Oct;163(2):425-30. J Pharmacol Exp Ther. 1968. PMID: 4878661 No abstract available.
-
Electrical stimulation of midbrain raphe: biochemical, behavioral and bioelectrical effects.Eur J Pharmacol. 1969 Aug;7(2):170-5. doi: 10.1016/0014-2999(69)90006-5. Eur J Pharmacol. 1969. PMID: 5345991 No abstract available.
-
Inhibition of serotonin reuptake.Fed Proc. 1977 Jul;36(8):2154-8. Fed Proc. 1977. PMID: 326579 Review.
Cited by
-
Potentiation of responses to monoamines by antidepressants after destruction of monoamine afferents.Br J Pharmacol. 1979 Mar;65(3):501-10. doi: 10.1111/j.1476-5381.1979.tb07858.x. Br J Pharmacol. 1979. PMID: 311665 Free PMC article.
-
Effect of cortical spreading depression on norepinephrine-H3 metabolism in brain stem.Experientia. 1968 Sep 15;24(9):909-10. doi: 10.1007/BF02138647. Experientia. 1968. PMID: 5709032 No abstract available.
-
Monoamine abnormalities in the SAPAP3 knockout model of obsessive-compulsive disorder-related behaviour.Philos Trans R Soc Lond B Biol Sci. 2018 Mar 19;373(1742):20170023. doi: 10.1098/rstb.2017.0023. Philos Trans R Soc Lond B Biol Sci. 2018. PMID: 29352023 Free PMC article.
-
Failure of decreased serotonin uptake or monoamine oxidase inhibition to block the acceleration in brain 5-hydroxyindole synthesis that follows food consumption.J Neural Transm. 1975;37(1):25-32. doi: 10.1007/BF01249763. J Neural Transm. 1975. PMID: 1159412
-
Mesopontine rostromedial tegmental nucleus neurons projecting to the dorsal raphe and pedunculopontine tegmental nucleus: psychostimulant-elicited Fos expression and collateralization.Brain Struct Funct. 2012 Jul;217(3):719-34. doi: 10.1007/s00429-011-0368-z. Epub 2011 Dec 18. Brain Struct Funct. 2012. PMID: 22179106 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources