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. 1968 Nov 1;162(3853):576-8.
doi: 10.1126/science.162.3853.576.

Erythromycin-resistant mutant of Escherichia coli with altered ribosomal protein component

K Tanaka, H Teraoka, M Tamaki, E Otaka, S Osawa

Erythromycin-resistant mutant of Escherichia coli with altered ribosomal protein component

K Tanaka et al. Science. .

Abstract

Erythromycin combines with 50S ribosomal subunit of an erythromycin-sensitive Escherichia coli (strain Q13), while ribosomes from an erythromycin-resistant mutant from this strain have little affinity for the antibiotic. A protein component of the 50S subunit of the mutant strain is distinct from that of the parent Q13 strain.

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