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. 1969 Mar;97(3):1234-41.
doi: 10.1128/jb.97.3.1234-1241.1969.

Regulator gene controlling enzymes concerned in tyrosine biosynthesis in Escherichia coli

B J Wallace, J Pittard

Regulator gene controlling enzymes concerned in tyrosine biosynthesis in Escherichia coli

B J Wallace et al. J Bacteriol. 1969 Mar.

Abstract

Mutants of Escherichia coli K-12 have been isolated in which several enzymes concerned with tyrosine biosynthesis are derepressed. These mutants were obtained from a parent strain possessing only a single 3-deoxy-d-arabinoheptulosonic acid-7-phosphate (DAHP) synthetase isoenzyme, DAHP synthetase (tyr), by selecting for resistance to the tyrosine analogue, 4-aminophenylalanine. The mutation responsible for this derepression has been mapped and the gene, which is not closely linked to aroF and tyrA, has been designated tyrR.

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