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. 1969 Mar;97(3):1242-7.
doi: 10.1128/jb.97.3.1242-1247.1969.

Inhibition of 3-deoxy-d-arabinoheptulosonic acid-7-phosphate synthetase (trp) in Escherichia coli

J Pittard, J Camakaris, B J Wallace

Inhibition of 3-deoxy-d-arabinoheptulosonic acid-7-phosphate synthetase (trp) in Escherichia coli

J Pittard et al. J Bacteriol. 1969 Mar.

Abstract

The growth of a strain of Escherichia coli K-12 which possesses only the single isoenzyme 3-deoxy-d-arabinoheptulosonic acid-7-phosphate (DAHP) synthetase (trp), and which makes this enzyme constitutively, is inhibited by tryptophan. The accumulation of DAHP by a derivative of this strain unable to convert DAHP to dehydroquinate is also inhibited by tryptophan. The enzymic activity of DAHP synthetase (trp) in the presence of CO(2+) is sensitive to inhibition by tryptophan. Mutant strains of E. coli have been isolated in which DAHP synthetase (trp) is feedback-resistant.

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References

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