Hypophosphataemia in septicaemia: higher incidence in gram-negative than in gram-positive infections

Abstract

Phosphataemia has been investigated in 54 patients with Gram-negative septicaemias; either absolute (serum phosphate <2 mg./100 ml.) or relative (P./B.U.N. 0.04) hypophosphataemia was found in 69% of all determinations. In 37 patients with Gram-positive septicaemias hypophosphataemia was present in only 24%, many of whom had additional Gram-negative bacteriuria and possible Gram-negative septicaemia suppressed by antibiotics. The mechanism of this phenomenon is not known. This new sign of Gram-negative septicaemia has some diagnostic importance.