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. 1969 May;98(2):587-92.
doi: 10.1128/jb.98.2.587-592.1969.

Chloramphenicol and the stimulation of ribonucleic acid synthesis in Escherichia coli

S Kaplan

Chloramphenicol and the stimulation of ribonucleic acid synthesis in Escherichia coli

S Kaplan. J Bacteriol. 1969 May.

Abstract

Data have been obtained which imply that chloramphenicol stimulation of ribonucleic acid (RNA) synthesis is a result of the accumulation of aminoacyl transfer RNA (tRNA) molecules. The data also support the hypothesis that chloramphenicol exerts an additional effect upon the stimulation of RNA synthesis. This effect may be at the level of the ribosome or the aminoacyl tRNA, or of both. It is this effect combined with the presence of aminoacyl tRNA that results in stimulation by chloramphenicol of RNA synthesis.

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References

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