doi: 10.1159/000232349.
Depression of contact hypersensitivity to oxazolone in mice exposed to Newcastle disease virus
- PMID: 489133
- DOI: 10.1159/000232349
Item in Clipboard
Depression of contact hypersensitivity to oxazolone in mice exposed to Newcastle disease virus
Int Arch Allergy Appl Immunol.
1979.
Abstract
The effect of Newcastle disease virus (NDV) on delayed hypersensitivity to oxazolone in CBA mice was studied. There was a significant impairment of the ability of mice to develop cutaneous hypersensitivity shortly after injection of the virus. The effect was evident when NDV was administered up to 2 days before or within 24 h after sensitization, suggesting that NDV interferes with the process of sensitization. The degree of depression was related to the dose of virus inoculated. NDV inactivated by UV irradiation or heat did not depress contact sensitivity to oxazolone. These data are considered to support the hypothesis that the depression is mediated by a direct interaction between lymphocytes and NDV.
Similar articles
-
Depression of contact sensitivity to oxazolone by the paramyxovirus of Newcastle disease. Impairment by infectious virus of effector T cells which mediate the response to contactant.Int Arch Allergy Appl Immunol. 1981;66(1):91-9. doi: 10.1159/000232804. Int Arch Allergy Appl Immunol. 1981. PMID: 6973547
-
Effects of high doses of peptichemio upon the humoral response to sheep erythrocytes and delayed hypersensitivity reactions to oxazolone in CBA mice.Tumori. 1977 Mar-Apr;63(2):147-54. doi: 10.1177/030089167706300204. Tumori. 1977. PMID: 898285
-
Pharmacological comparison of the immune and non-immune inflammations induced by picryl chloride and oxazolone in mice.Arch Int Pharmacodyn Ther. 1984 May;269(1):153-66. Arch Int Pharmacodyn Ther. 1984. PMID: 6466004
-
Fine-specificity of the immune response to oxazolone. I. Contact sensitivity and early antibodies.J Immunol. 1981 Dec;127(6):2366-71. J Immunol. 1981. PMID: 7299129
-
Comparison of sensitizing protocols for ultraviolet B-induced immunosuppression in C3H mice.Photodermatol Photoimmunol Photomed. 1994 Jun;10(3):106-10. Photodermatol Photoimmunol Photomed. 1994. PMID: 7947189 Review.
Cited by
-
Impairment of contrasuppressor activity in mice infected with the paramyxovirus of Newcastle disease.Immunology. 1992 Feb;75(2):245-9. Immunology. 1992. PMID: 1551687 Free PMC article.
-
Inhibition of lymphocyte mitogenesis in mice infected with Newcastle disease virus: viral interference with the interleukin system.Immunology. 1986 Mar;57(3):373-8. Immunology. 1986. PMID: 2937717 Free PMC article.
-
Analysis of the T suppressor cell circuit which regulates contact sensitivity in mice infected with the virus of Newcastle disease.Immunology. 1984 Feb;51(2):305-11. Immunology. 1984. PMID: 6229474 Free PMC article.