Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1969 Jun;63(2):481-8.
doi: 10.1073/pnas.63.2.481.

Studies on repression of the histidine operon. II. The role of the first enzyme in control of the histidine system

J S Kovach, J M Phang, M Ference, R F Goldberger

Studies on repression of the histidine operon. II. The role of the first enzyme in control of the histidine system

J S Kovach et al. Proc Natl Acad Sci U S A. 1969 Jun.

Abstract

Recent studies on repression of the enzymes for histidine bio-synthesis in Salmonella typhimurium demonstrated that the kinetic pattern in which the enzymes become repressed is influenced by the state of the feedback-sensitive site of the first enzyme of the pathway (Kovach et al., J. Bacteriol., 97, 1283 (1969)). In the present study we demonstrate that under certain conditions alteration of the feedback-sensitive site of the first enzyme prevents repression of the histidine operon. We conclude that the first enzyme plays a previously unrecognized role in regulation of the histidine system.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Mol Biol. 1966 Dec 28;22(2):335-47 - PubMed
    1. J Biol Chem. 1961 Aug;236:2261-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1965 Aug;54(2):451-7 - PubMed
    1. Cold Spring Harb Symp Quant Biol. 1966;31:321-33 - PubMed
    1. J Mol Biol. 1967 Nov 28;30(1):97-107 - PubMed

LinkOut - more resources