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. 1979 Aug-Sep;19(8-9 Pt 2):513-5.
doi: 10.1002/j.1552-4604.1979.tb02516.x.

Blunting of exercise-induced tachycardia and renin release 24 hours after a single dose of sotalol

W Kiowski, F R Bühler, P Van Brummelen, M Küng

Blunting of exercise-induced tachycardia and renin release 24 hours after a single dose of sotalol

W Kiowski et al. J Clin Pharmacol. 1979 Aug-Sep.

Abstract

Sotalol significantly reduces resting and exercise-stimulated heart rate and plasma renin activity 2 hours and to a lesser degree also 24 hours after oral administration of a single 200-mg dose in healthy volunteers. Because of this 24-hour beta-adrenoceptor blocking effect, sotalol should be suitable for once-daily dosing in clinical practice.

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