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Clinical Trial
. 1969 Oct 25;4(5677):206-7.
doi: 10.1136/bmj.4.5677.206.

Topical ampicillin in the appendicectomy wound: report of double-blind trial

J W Rickett, B T Jackson
Clinical Trial

Topical ampicillin in the appendicectomy wound: report of double-blind trial

J W Rickett et al. Br Med J. .

Abstract

One hundred and thirty unselected patients undergoing appendicectomy were treated with topical ampicillin powder or topical placebo powder (lactose) before closing the wound. The postoperative wound infection rates were 3% in the ampicillin-treated group and 24% in the control group, a significant difference. This difference was not influenced by the degree of inflammation in the appendix. No side-effects of treatment were observed.

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