doi: 10.1093/jn/109.10.1787.
On the physiological basis of vitamin A-stimulated growth
- PMID: 490215
- DOI: 10.1093/jn/109.10.1787
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On the physiological basis of vitamin A-stimulated growth
J Nutr.
1979 Oct.
Abstract
The influence of vitamin A depletion on tissue composition was studied in rats that were marginally vitamin A deficient, i.e. at their weight plateau stage. The total number of cells (DNA) was decreased in most organs as a result of vitamin A depletion. In thymus, spleen and the sublingual glands there was also a dramatic reduction in the number of cells per gram of tissue and in thymus and sublingual glands there was an increase in the protein to DNA ratio as a result of absence of dietary.vitamin A. We present the hypothesis that vitamin A stimulates growth by a direct role in cell replication in addition to or instead of stimulating the differentiation of epithelial and bone cells.
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