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. 1969 Nov;100(2):1144-6.
doi: 10.1128/jb.100.2.1144-1146.1969.

Aminoglycoside antibiotics: inactivation by phosphorylation in Escherichia coli carrying R factors

B Ozanne, R Benveniste, D Tipper, J Davies

Aminoglycoside antibiotics: inactivation by phosphorylation in Escherichia coli carrying R factors

B Ozanne et al. J Bacteriol. 1969 Nov.

Abstract

R-factor strains which are streptomycin-resistant and spectinomycin-sensitive have been found to inactivate streptomycin by a new mechanism. The 3'-OH group of the 2-deoxy-2-methylamino-l-glucopyranosyl moiety is phosphorylated.

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References

    1. J Biol Chem. 1966 Jul 10;241(13):3055-62 - PubMed
    1. Nature. 1965 Dec 25;208(5017):1301-3 - PubMed
    1. Science. 1967 Sep 29;157(3796):1559-61 - PubMed
    1. J Antibiot (Tokyo). 1967 Jul;20(3):132-5 - PubMed
    1. J Antibiot (Tokyo). 1967 Jul;20(3):136-41 - PubMed

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