Antileukemic activity of derivatives of 1,2-dimethyl-3,4-bis(hydroxymethyl)-5-phenylpyrrole bis(N-methylcarbamate)

Abstract

A series of phenyl-substituted derivatives of 1,2-dimethyl-3,4-bis(hydroxymethyl)-5-phenylpyrrole bis(N-methylcarbamate) (1) were synthesized and tested for antileukemic activity against P388 lymphocytic leukemia in the mouse. All of the compounds tested, 1a--r, showed significant activity in this assay. Selected derivatives of 1 were tested against several bacteria and were found to have little or no antibacterial activity in the systems examined.