Colicin-tolerant mutants of Escherichia coli: resistance of membranes to colicin E1
- PMID: 4909623
- DOI: 10.1126/science.168.3934.998
Colicin-tolerant mutants of Escherichia coli: resistance of membranes to colicin E1
Abstract
Colicin E1 blocks proline accumulation by membrane vesicles prepared from wild-type sensitive Escherichia coli. Two classes of mutant cells are unaffected by colicin. Vesicles from colicin-resistant strains are sensitive to colicin E1, whereas vesicles from colicin-tolerant strains are unaffected by colicin El. These results suggest that the colicin E1 receptor is on the cell membrane and that colicin-tolerant strains have altered membranes while colicin-resistant strains have altered cell walls.
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