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. 1970 May 22;168(3934):998-1000.
doi: 10.1126/science.168.3934.998.

Colicin-tolerant mutants of Escherichia coli: resistance of membranes to colicin E1

P Bhattacharyya, L Wendt, E Whitney, S Silver

Colicin-tolerant mutants of Escherichia coli: resistance of membranes to colicin E1

P Bhattacharyya et al. Science. .

Abstract

Colicin E1 blocks proline accumulation by membrane vesicles prepared from wild-type sensitive Escherichia coli. Two classes of mutant cells are unaffected by colicin. Vesicles from colicin-resistant strains are sensitive to colicin E1, whereas vesicles from colicin-tolerant strains are unaffected by colicin El. These results suggest that the colicin E1 receptor is on the cell membrane and that colicin-tolerant strains have altered membranes while colicin-resistant strains have altered cell walls.

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