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. 1970 May 29;168(3935):1095-6.
doi: 10.1126/science.168.3935.1095.

Cross-reactions between streptococcal M proteins and human transplantation antigens

A A Hirata, P I Terasaki

Cross-reactions between streptococcal M proteins and human transplantation antigens

A A Hirata et al. Science. .

Abstract

Allogeneic antiserums against human lymphocytes were specifically inhibited by M protein from beta hemolytic group A Streptococcus pyogenes, type 1. Analogous M proteins from streptococcus types 3, 4, 5, 6, 12, and 14 had little or no inhibitory activity. The specific inhibition by M protein is not a result of anticomplementary activity or of coating of the lymphocyte surface. Streptococcal polysaccharide and 73 other polysaccharides were inactive. Because all seven HL-A specificities tested were inhibited, it is inferred that M1 protein has a structure common to human histocompatibility antigens.

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