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. 1968 Mar;2(3):178-81.
doi: 10.1128/JVI.2.3.178-181.1968.

Enhancement of St. Louis arbovirus plaque formation by neutral red

Enhancement of St. Louis arbovirus plaque formation by neutral red

M Marcovici et al. J Virol. 1968 Mar.

Abstract

Experiments with St. Louis encephalitis (SLE) virus have shown that neutral red enhances the plaque size in duck embryo cell cultures. This may represent a new method for genetic studies of SLE virus population. In a mosquito pool specimen NR(+) and NR(-) particles were demonstrated. By intracerebral passage in mice, there is a selection of NR(+) particles. Similar effects were not shown for eastern, western, and California encephalitis viruses. Plaques formed by the latter virus, however, were significantly reduced in number by neutral red.

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