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. 1970 Jun 26;168(3939):1595-7.
doi: 10.1126/science.168.3939.1595.

Mouse lysozyme production by a monocytoma: isolation and comparison with other lysozymes

R J Riblet, L A Herzenberg

Mouse lysozyme production by a monocytoma: isolation and comparison with other lysozymes

R J Riblet et al. Science. .

Abstract

A transplantable mouse tumor, GPC-11, produces large amounts of lysozyme. The tumor is a reticulum cell sarcoma, type A, and is a neoplasm of monocytes. The lysozyme was purified from mouse urine in quantities sufficient for structural analysis. Comparison of mouse lysozyme with lysozymes from; chicken egg white and patients with monocytic leukemia reveals similarities in size and electrophoretic mobility and, with human lysozyme, in functional properties; but considerable differences are found in antigenic characteristics and amino acid composition.

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