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. 1970 Jul 24;169(3943):392-5.
doi: 10.1126/science.169.3943.392.

Visualization of bacterial genes in action

O L Miller Jr, B A Hamkalo, C A Thomas Jr

Visualization of bacterial genes in action

O L Miller Jr et al. Science. .

Abstract

The morphology of active structural and putative ribosomal RNA genes was observed by electron microscopy after lysis of fragile Escherichia coli cells. Conclusions drawn are: most of the chromosome is not genetically active at any one instant; translation is completely coupled with transcription; the 16S and 23S ribosomal RNA cistrons occur in tandem, in regions which are widely spaced on the chromosome.

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