doi: 10.1073/pnas.66.4.1220.
Mapping of a human genetic regulator element by somatic cell genetic analysis
- PMID: 4920091
- PMCID: PMC335809
- DOI: 10.1073/pnas.66.4.1220
Item in Clipboard
Mapping of a human genetic regulator element by somatic cell genetic analysis
Proc Natl Acad Sci U S A.
1970 Aug.
Abstract
The ES-2 esterase is a kidney-associated esterase and is expressed in a cloned mouse renal adenocarcinoma cell line. Somatic cell hybridization of the mouse renal adenocarcinoma with either mouse or human fibroblasts leads to the marked reduction of ES-2 esterase titer. The extinction of ES-2 esterase activity in mousexhuman hybrids is reversible. Extinction correlates with the presence of the human C(10) chromosome in the somatic cell hybrids; whereas reexpression of the ES-2 esterase is observed in hybrids which have lost C(10). Thus, the proposed regulator element involved is probably structurally linked to C(10); however, linkage to a member of the D or G groups cannot be completely excluded.
Similar articles
-
Genetics of human-mouse somatic cell hybrids: linkage of human genes for lactate dehydrogenase-A and esterase-A 4.Proc Natl Acad Sci U S A. 1972 Feb;69(2):348-52. doi: 10.1073/pnas.69.2.348. Proc Natl Acad Sci U S A. 1972. PMID: 4501118 Free PMC article.
-
Prospects for the chromosomal localization of human genes in human-mouse somatic cell hybrids.Wistar Inst Symp Monogr. 1969;9:51-9. Wistar Inst Symp Monogr. 1969. PMID: 5408739 No abstract available.
-
Polymorphism of esterase 11 in Mus musculus, a further esterase locus on chromosome 8.Biochem Genet. 1977 Apr;15(3-4):217-26. doi: 10.1007/BF00484454. Biochem Genet. 1977. PMID: 869894
-
Genetics of somatic mammalian cells: demonstration of a human esterase activator gene linked to the adeB gene.Proc Natl Acad Sci U S A. 1972 Nov;69(11):3273-7. doi: 10.1073/pnas.69.11.3273. Proc Natl Acad Sci U S A. 1972. PMID: 4508320 Free PMC article.
-
Assignment of three human genes to chromosomes (LDH-A to 11, TK to 17, and IDH to 20) and evidence for translocation between human and mouse chromosomes in somatic cell hybrids (thymidine kinase-lactate dehydrogenase A-isocitrate dehydrogenase-C-11, E-17, and F-20 chromosomes).Proc Natl Acad Sci U S A. 1972 Feb;69(2):510-4. doi: 10.1073/pnas.69.2.510. Proc Natl Acad Sci U S A. 1972. PMID: 4110482 Free PMC article.
Cited by
-
Gene dosage dependence of pigment synthesis in melanoma x fibroblast hybrids (hamster cells-mouse fibroblast-DOPA-oxidase-irradiation).Proc Natl Acad Sci U S A. 1972 Feb;69(2):330-4. doi: 10.1073/pnas.69.2.330. Proc Natl Acad Sci U S A. 1972. PMID: 4621832 Free PMC article.
-
Cell fusion and some subcellular properties of heterokaryons and hybrids.J Cell Biol. 1975 Nov;67(2PT.1):257-80. doi: 10.1083/jcb.67.2.257. J Cell Biol. 1975. PMID: 1104638 Free PMC article. Review. No abstract available.
-
Somatic hybridization as a tool for the study of differentiation: a review.Biochem J. 1971 Oct;124(5):39P. doi: 10.1042/bj1240039pa. Biochem J. 1971. PMID: 5167134 Free PMC article. No abstract available.
-
Expression of differentiated functions in hepatoma cell hybrids: induction of mouse albumin production in rat hepatoma-mouse fibroblast hybrids.Proc Natl Acad Sci U S A. 1972 Mar;69(3):571-5. doi: 10.1073/pnas.69.3.571. Proc Natl Acad Sci U S A. 1972. PMID: 4335066 Free PMC article.
-
Utilization of somatic cell hybrids for genetic studies in man.Humangenetik. 1973;19(1):1-40. doi: 10.1007/BF00295233. Humangenetik. 1973. PMID: 4353600 Review. No abstract available.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials
