Review
doi: 10.1136/pgmj.46.537.409.
Aminoglutethimide: a "side-effect" turned to therapeutic advantage
- PMID: 4920933
- PMCID: PMC2467063
- DOI: 10.1136/pgmj.46.537.409
Item in Clipboard
Review
Aminoglutethimide: a "side-effect" turned to therapeutic advantage
Postgrad Med J.
1970 Jul.
Abstract
Aminoglutethimide was introduced as an anti-convulsant drug in the U.S.A. in 1960.
The occurrence of a number of side-effects, including several endocrine effects such as goitrogenesis, sexual precocity and virilization, led to its withdrawal.
Further investigation indicated that the drug inhibited adrenal biosynthesis, particularly of aldosterone, cortisol and androgens, probably by interfering with the conversion of cholesterol to delta-5-pregnenolone.
Aminoglutethimide has also been shown to modify the extra-adrenal metabolism of cortisol.
The possible clinical applications of these ‘side-effects’ are discussed.
Similar articles
-
[Clinical and biological study of an inhibitor of adrenocortical hormone synthesis: aminoglutethinide].Ann Endocrinol (Paris). 1968 Mar-Apr;29(2):189-210. Ann Endocrinol (Paris). 1968. PMID: 4298418 Clinical Trial. French. No abstract available.
-
The treatment of congenital adrenal hyperplasia with aminoglutethimide.Q J Med. 1971 Oct;40(160):568-9. Q J Med. 1971. PMID: 5157412 No abstract available.
-
[Corticosteroidogenesis inhibitors. II. A new cortico-adrenal inhibitor: amino-glutethimide (16,038Ba)].Presse Med (1893). 1968 May 11;76(23):1107-10. Presse Med (1893). 1968. PMID: 5657304 French. No abstract available.
-
[Inhibition of adrenocortical steroid production in therapy].Rev Fr Etud Clin Biol. 1968 Jun-Jul;13(6):563-7. Rev Fr Etud Clin Biol. 1968. PMID: 4178146 Review. French. No abstract available.
-
Aminoglutethimide: review of pharmacology and clinical use.Pharmacotherapy. 1981 Sep-Oct;1(2):95-120. doi: 10.1002/j.1875-9114.1981.tb03557.x. Pharmacotherapy. 1981. PMID: 6765487 Review.
Cited by
-
Suppression of estrogens with aminoglutethimide and hydrocortisone (medical adrenalectomy) as treatment of advanced breast carcinoma: a review.Breast Cancer Res Treat. 1981;1(3):183-202. doi: 10.1007/BF01806259. Breast Cancer Res Treat. 1981. PMID: 6293627 Review.
-
Mechanisms of action of aminoglutethimide as endocrine therapy of breast cancer.Drugs. 1988 Jun;35(6):685-710. doi: 10.2165/00003495-198835060-00005. Drugs. 1988. PMID: 3048976 Review.
-
Could aminoglutethimide replace adrenalectomy?Breast Cancer Res Treat. 1985;6(3):201-11. doi: 10.1007/BF01806770. Breast Cancer Res Treat. 1985. PMID: 3912013 Review.
-
Drug-induced endocrine disorders.Drugs. 1977 May;13(5):353-65. doi: 10.2165/00003495-197713050-00002. Drugs. 1977. PMID: 194765 Review. No abstract available.
-
Towards understanding aromatase inhibitory activity via QSAR modeling.EXCLI J. 2018 Jul 20;17:688-708. doi: 10.17179/excli2018-1417. eCollection 2018. EXCLI J. 2018. PMID: 30190660 Free PMC article. Review.
