Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1971 Jan 1;133(1):113-32.
doi: 10.1084/jem.133.1.113.

Wild-type Gross leukemia virus and the pathogenesis of the glomerulonephritis of New Zealand mice

R C Mellors, T Shirai, T Aoki, R J Huebner, K Krawczynski

Wild-type Gross leukemia virus and the pathogenesis of the glomerulonephritis of New Zealand mice

R C Mellors et al. J Exp Med. .

Abstract

The pathogenesis of the spontaneous glomerulonephritis of NZB and (NZB x NZW) F(1) hybrid mice is related at least in part to the formation of natural antibody against antigens of the G (Gross) system, and apparently to the deposition in the glomeruli of immune complexes of G natural antibody with G soluble antigen (GSA), type-specific antigen specified by wild-type Gross leukemia virus. G natural antibody and GSA are detectable in the acid-buffer eluate of the kidneys of NZB mice during the course of the glomerulonephritis. (NZB x NZW) F(1) hybrid mice develop glomerulonephritis and produce GSA and free G natural antibody earlier in life than do NZB mice. The proteinuria manifestation of the gomerulonephritis of (NZB x NZW) F(1) hybrid mice becomes increasingly prevalent as GSA undergoes immune elimination from the circulation. Gross leukemia virus-specified antigens together with bound immunoglobulins are located in the glomerular lesions of (NZB x NZW) F(1) hybrid mice, both in the mesangium as observed in NZB mice and also in the wall of the peripheral capillary loops of the glomeruli.

PubMed Disclaimer

References

    1. Immunochemistry. 1965 Sep;2(3):235-54 - PubMed
    1. J Exp Med. 1969 May 1;129(5):1045-62 - PubMed
    1. Cancer Res. 1966 Jul;26(7):1415-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1965 May;53(5):931-8 - PubMed
    1. J Exp Med. 1966 Oct 1;124(4):753-72 - PubMed

MeSH terms