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Clinical Trial
. 1970 Dec 26;4(5738):776-80.
doi: 10.1136/bmj.4.5738.776.

Treatment of zoster with idoxuridine in dimethyl sulphoxide. Results of two double-blind controlled trials

B E Juel-Jensen, F O MacCallum, A M Mackenzie, M C Pike
Clinical Trial

Treatment of zoster with idoxuridine in dimethyl sulphoxide. Results of two double-blind controlled trials

B E Juel-Jensen et al. Br Med J. .

Abstract

The antiviral effect of 5% idoxuridine in dimethyl sulphoxide intermittently applied and of 40% idoxuridine in dimethyl sulphoxide continuously applied for four days to the lesions in patients with zoster of recent onset was studied in two double-blind controlled trials. Most, but not all, of the patients receiving intermittent active treatment had pain for a short period only. The effect of continuous treatment was striking: pain had disappeared within nine days in all the patients and healing was accelerated. The results were statistically significant.

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