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. 1970 Dec 1;132(6):1250-8.
doi: 10.1084/jem.132.6.1250.

Transformation of fibroblasts by allogeneic and xenogeneic transplants of demineralized tooth and bone

C Huggins, S Wiseman, A H Reddi

Transformation of fibroblasts by allogeneic and xenogeneic transplants of demineralized tooth and bone

C Huggins et al. J Exp Med. .

Abstract

Xenogeneic transplants of powdered, dehydrated, demineralized matrix of bone and tooth were well tolerated in three species of rodents. Differences between the species were found in competence of fibroblasts to be transformed into cartilage and bone in vivo by these preparations. Rat fibroblasts were most susceptible to transformation of this sort; they were transformed by demineralized dentin of guinea pig, mouse, and rat, and to a limited extent, by a specimen of decalcified human bone.

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References

    1. Science. 1965 Nov 12;150(3698):893-9 - PubMed
    1. J Exp Med. 1961 Nov 1;114:741-60 - PubMed
    1. Nature. 1970 Mar 14;225(5237):1051-2 - PubMed
    1. Science. 1970 Feb 6;167(3919):896-8 - PubMed
    1. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed