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. 1971 May 21;172(3985):854-5.
doi: 10.1126/science.172.3985.854.

Cross-linked transfer RNA functions in all steps of the translation process

L J Chaffin, D R Omilianowski, R M Bock

Cross-linked transfer RNA functions in all steps of the translation process

L J Chaffin et al. Science. .

Abstract

A specific photochemical reaction between 4-thiouridine and cytosine cross-links two arms of transfer RNA. This cross-link, introduced into phenylalanine transfer RNA and arginine transfer RNA, limits the conformational freedom of the molecule. Both modified transfer RNA's are capable of functioning in all steps of protein synthesis with this restraint on allowable conformations.

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