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. 1971 Jun;106(3):972-82.
doi: 10.1128/jb.106.3.972-982.1971.

Biochemical bases for the antimetabolite action of L-serine hydroxamate

T Tosa, L I Pizer

Biochemical bases for the antimetabolite action of L-serine hydroxamate

T Tosa et al. J Bacteriol. 1971 Jun.

Abstract

The amino acid analogue l-serine hydroxamate, which is bacteriostatic for Escherichia coli, has been shown to inhibit protein synthesis. The antimetabolite is a competitive inhibitor of seryl-transfer ribonucleic acid (tRNA) synthetase with a K(i) value of 30 mum. Mutants resistant to l-serine hydroxamate have been selected, and three were shown to have seryl-tRNA synthetases with increased K(i) values. One mutant contains a 3-phosphoglycerate dehydrogenase which is insensitive to inhibition by l-serine.

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