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. 1971 Sep;21(3):427-36.

Acute antigen-induced elevation of serum colony stimulating factor (CFS) levels

D Metcalf

Acute antigen-induced elevation of serum colony stimulating factor (CFS) levels

D Metcalf. Immunology. 1971 Sep.

Abstract

Injection of endotoxin or Salmonella flagellins to C57BL mice caused 50–100-fold elevations, maximal at 3–9 hours, in the capacity of the serum to stimulate granulocyte and macrophage colony formation by mouse bone marrow cells in agar cultures. This response was not elicited by a variety of foreign serum proteins. The response was radioresistant but preimmunized mice showed a specific depression of responsiveness on challenge with the same antigen.

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