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Clinical Trial
. 1971 Sep 11;3(5775):599-604.
doi: 10.1136/bmj.3.5775.599.

Trial of maintenance therapy in schizophrenia

J P Leff, J K Wing
Clinical Trial

Trial of maintenance therapy in schizophrenia

J P Leff et al. Br Med J. .

Abstract

A double-blind, placebo-controlled trial was carried out to determine the value of maintenance therapy with phenothiazines in a population of outpatients who had recently recovered from an acute episode of schizophrenia. The drug was shown to be significantly more effective than the placebo in preventing relapse. The relationship of the trial patients to the population from which they were selected was defined in terms of clinical, historical, and social data. Maintenance therapy seems of little value in patients with a good prognosis and in the severely ill, but it is of value in the indeterminate group between these two extremes.

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References

    1. Br Med J. 1962 Apr 7;1(5283):972-6 - PubMed
    1. Br Med J. 1965 Oct 2;2(5465):790-2 - PubMed
    1. Arch Gen Psychiatry. 1964 Aug;11:162-9 - PubMed
    1. Am J Psychiatry. 1958 Nov;115(5):443-8 - PubMed
    1. Am J Psychiatry. 1960 Nov;117:444-7 - PubMed

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