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Clinical Trial
. 1971 Sep 25;3(5777):729-32.
doi: 10.1136/bmj.3.5777.729.

Idiopathic Parkinsonism treated with an extracerebral decarboxylase inhibitor in combination with levodopa

D B Calne, J L Reid, S D Vakil, S Rao, A Petrie, C A Pallis, J Gawler, P K Thomas, A Hilson
Clinical Trial

Idiopathic Parkinsonism treated with an extracerebral decarboxylase inhibitor in combination with levodopa

D B Calne et al. Br Med J. .

Abstract

The clinical actions of levodopa in Parkinsonism, given with and without an extracerebral decarboxylase in hibitor, L-alpha-methyldopahydrazine, were compared. Twenty-one patients were investigated in a "double-blind cross-over" study, administering levodopa in maximum tolerated dosage. L-Alpha-methyldopahydrazine failed to augment the overall therapeutic actions of levodopa but it consistently alleviated nausea. It is concluded that L-alpha-methyldopahydrazine will prove useful in the management of some Parkinsonian patients who have difficulty in taking levodopa alone.

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References

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