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. 1971 Aug;107(2):391-6.
doi: 10.1128/jb.107.2.391-396.1971.

Growth rate of Escherichia coli at elevated temperatures: limitation by methionine

E Z Ron, B D Davis

Growth rate of Escherichia coli at elevated temperatures: limitation by methionine

E Z Ron et al. J Bacteriol. 1971 Aug.

Abstract

When Escherichia coli growing in minimal medium is shifted from 37 C to any temperature in the range 40 to 45 C, the growth rate immediately assumes a new, lower value, characteristic of that temperature. The decrease is shown to be due, in several strains, to decreased activity of the first enzyme of the methionine pathway, homoserine trans-succinylase, which thus appears to be more heat-sensitive than any other essential enzyme in the cell. This sensitivity does not involve progressive denaturation of the enzyme; rather, the response to a shift of temperature, in either direction, is immediate and reversible.

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References

    1. J Gen Microbiol. 1966 Jan;42(1):155-63 - PubMed
    1. J Mol Biol. 1966 Oct 28;21(1):13-27 - PubMed
    1. J Bacteriol. 1967 Aug;94(2):327-32 - PubMed
    1. J Bacteriol. 1971 Aug;107(2):397-400 - PubMed
    1. Proc Natl Acad Sci U S A. 1961 Dec 15;47:2005-14 - PubMed

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