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. 1979 Nov 30;206(4422):1089-91.
doi: 10.1126/science.493994.

Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter

L P Yotti, C C Chang, J E Trosko

Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter

L P Yotti et al. Science. .

Abstract

Wild-type Chinese hamster V79 cells (6-thioguanine-sensitive) reduce the recovery of 6-thioguanine-resistant cells when they are cultured together at high densities, through a form of intercellular communication (metabolic cooperation). Cooperation is inhibited by 12-O-tetradecanoyl phorbol-13-acetate, rescuing the 6-thioguanine-resistant cells. These results may be useful in the study of an aspect of the mechanism of tumor promotion and in assaying for promoters.

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