doi: 10.1126/science.493994.
Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter
- PMID: 493994
- DOI: 10.1126/science.493994
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Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter
Science.
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Abstract
Wild-type Chinese hamster V79 cells (6-thioguanine-sensitive) reduce the recovery of 6-thioguanine-resistant cells when they are cultured together at high densities, through a form of intercellular communication (metabolic cooperation). Cooperation is inhibited by 12-O-tetradecanoyl phorbol-13-acetate, rescuing the 6-thioguanine-resistant cells. These results may be useful in the study of an aspect of the mechanism of tumor promotion and in assaying for promoters.
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