doi: 10.1126/science.174.4005.139.
L-asparaginase induced immunosuppression: inhibition of bone marrow derived antibody precursor cells
- PMID: 4940962
- DOI: 10.1126/science.174.4005.139
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L-asparaginase induced immunosuppression: inhibition of bone marrow derived antibody precursor cells
Science.
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Abstract
The cooperation between bone marrow and thymus cells in restoring the hemolytic antibody response to sheep erythrocytes in immunosuppressed recipients was markedly inhibited when donor mice were treated with L-asparaginase, a known inhibitor of lymphocyte function. The marrow cell population was shown to be a major target for the immunosuppressive activity of asparaginase, since thymus cells from enzyme-treated animals interacted with marrow cells from normal animals to generate immunocompetent cells.
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