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. 1971 Oct;9(4):483-98.

Lymphocyte activation. I. Response of T and B lymphocytes to phytomitogens

G Janossy, M F Greaves

Lymphocyte activation. I. Response of T and B lymphocytes to phytomitogens

G Janossy et al. Clin Exp Immunol. 1971 Oct.

Abstract

The selectivity of phytomitogens for T (thymus derived/dependent) and B (`bursa-equivalent' dependent/derived) lymphocytes from the mouse spleen has been investigated. Responses of normal spleen cell cultures were compared with those of cultures of selected B cells. The latter were obtained from three sources (1) spleen cells of mice that had been thymectomized as adults, lethally irradiated and reconstituted with syngeneic bone marrow cells pretreated with anti-θ serum (2) spleen cells from congenitally athymic (`nude') mice and (3) spleen cells from normal mice treated with anti-θ serum plus guinea-pig complement prior to culture.

Using a variety of different culture conditions it was shown that B cells respond well to pokeweed mitogen, and poorly if at all to phytohaemagglutinin. Responsiveness to the latter mitogen in normal spleen cell cultures appears to be a property of T cells.

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References

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