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. 1971 Aug;68(8):1665-9.
doi: 10.1073/pnas.68.8.1665.

Specific heterologous enhancement of immune responses

A S Rubin, A H Coons

Specific heterologous enhancement of immune responses

A S Rubin et al. Proc Natl Acad Sci U S A. 1971 Aug.

Abstract

In suspension cultures of mouse spleen cells, the addition of small amounts (1-100 ng) of a heterologous antigen to which the donor mice had been primed significantly increased the number of anti-sheep erythrocyte plaques appearing after stimulation with sheep erythrocytes. A similar addition to identical cultures from unprimed donors produced a small depression in the number of such plaques.

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References

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