doi: 10.1073/pnas.68.8.1665.
Specific heterologous enhancement of immune responses
- PMID: 4942910
- PMCID: PMC389266
- DOI: 10.1073/pnas.68.8.1665
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Specific heterologous enhancement of immune responses
Proc Natl Acad Sci U S A.
1971 Aug.
Abstract
In suspension cultures of mouse spleen cells, the addition of small amounts (1-100 ng) of a heterologous antigen to which the donor mice had been primed significantly increased the number of anti-sheep erythrocyte plaques appearing after stimulation with sheep erythrocytes. A similar addition to identical cultures from unprimed donors produced a small depression in the number of such plaques.
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