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. 1971 Dec;68(12):2954-7.
doi: 10.1073/pnas.68.12.2954.

Slow joining of newly replicated DNA chains in DNA polymerase I-deficient Escherichia coli mutants

R Okazaki, M Arisawa, A Sugino

Slow joining of newly replicated DNA chains in DNA polymerase I-deficient Escherichia coli mutants

R Okazaki et al. Proc Natl Acad Sci U S A. 1971 Dec.

Abstract

In Escherichia coli mutants deficient in DNA polymerase I, newly replicated short DNA is joined at about 10% of the rate in the wild-type strains. It is postulated that DNA polymerase I normally functions in filling gaps between the nascent short segments synthesized by the replication complex. Possible implications of the finding are discussed in relation to other abnormal properties of these mutants.

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References

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