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. 1971 Dec;22(6):957-62.
doi: 10.1128/am.22.6.957-962.1971.

Effects of actinobolin on growth and some metabolic activities of cariogenic streptococci in vitro and in vivo

B B Keele Jr, H L Powell Jr, J M Navia, J McGhee

Effects of actinobolin on growth and some metabolic activities of cariogenic streptococci in vitro and in vivo

B B Keele Jr et al. Appl Microbiol. 1971 Dec.

Abstract

Actinobolin, a known inhibitor of protein synthesis, has been shown not to interfere selectively with acid production or dextransucrase activity in a cariogenic streptococcus when the antibiotic is added to a concentration of 500 mug/ml. It has also been shown that actinobolin does not alter the total in vivo flora of the oral cavity of the rat when tested in a rat caries model system. A culture of cariogenic streptococci, adapted to in vitro growth in the presence of 1 mg of actinobolin per ml, has also been isolated.

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References

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    1. J Nutr. 1969 Jan;97(1):133-40 - PubMed
    1. Arch Oral Biol. 1969 May;14(5):469-78 - PubMed
    1. J Am Dent Assoc. 1969 Dec;79(6):1395-404 - PubMed
    1. J Dent Res. 1970 Jan-Feb;49(1):137-9 - PubMed

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