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. 1979 Aug;26(4):323-5.

The effect of ethanol ingestion on plasma biochemistry and the pancreas in the rat

S N Joffe, M M Ferrie, R O'Hare
  • PMID: 495029

The effect of ethanol ingestion on plasma biochemistry and the pancreas in the rat

S N Joffe et al. Acta Hepatogastroenterol (Stuttg). 1979 Aug.

Abstract

Intra-gastric ethanol given daily for 4 weeks caused transient elevations in plasma amylase and total protein with a fall in total calcium. Light microscopic examination of the pancreas at 4 weeks showed areas of acinar cell degranulation and necrosis without an inflammatory cell infiltrate. The pancreatic changes are unlikely to be an artefact, but rather a direct toxic effect of the alcohol as confirmed by the biochemical changes.

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