Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Aug;9(3):253-6.
doi: 10.1007/BF01966697.

Histamine H1-and H2-receptors in coronary arteries of pigs

M Hagen, I Paegelow

Histamine H1-and H2-receptors in coronary arteries of pigs

M Hagen et al. Agents Actions. 1979 Aug.

Abstract

Histamine exerts its action in smooth muscle via in two types of receptors. In coronary arteries of pigs both types of receptors are also involved in responses to histamine. Histamine initiates by an interaction with H1-receptors a contraction and with H2-receptors a relaxation. The histamine-induced contraction is reduced by the competitively antagonistic action of mepyramine. Metiamide potentiates dose-dependently the histamine-caused contraction in the absence and presence of mepyramine. The proportion of H2-receptors in relation to H1-receptors is calculated.

PubMed Disclaimer

References

    1. Agents Actions. 1975 Oct;5(4):277-95 - PubMed
    1. Br J Pharmacol. 1975 Oct;55(2):173-9 - PubMed
    1. Nature. 1972 Apr 21;236(5347):385-90 - PubMed
    1. Fed Proc. 1976 Jun;35(8):1935-41 - PubMed
    1. Br J Pharmacol. 1974 May;51(1):123P-124P - PubMed

MeSH terms