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. 1966 Jan 21;151(3708):347-9.
doi: 10.1126/science.151.3708.347.

Chloroquine: mode of action

J Ciak, F E Hahn

Chloroquine: mode of action

J Ciak et al. Science. .

Abstract

The drug chloroquine is bactericidal for Bacillus megaterium; it inhibits DNA and RNA biosynthesis and produces rapid degradation of ribosomes and dissimilation of ribosomal RNA. Inhibition of protein synthesis is also observed, evidently as a secondary effect. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine.

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