doi: 10.1126/science.151.3708.347.
Chloroquine: mode of action
- PMID: 4955293
- DOI: 10.1126/science.151.3708.347
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Chloroquine: mode of action
Science.
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Abstract
The drug chloroquine is bactericidal for Bacillus megaterium; it inhibits DNA and RNA biosynthesis and produces rapid degradation of ribosomes and dissimilation of ribosomal RNA. Inhibition of protein synthesis is also observed, evidently as a secondary effect. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine.
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