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. 1966 Jan 7;151(3706):89-91.
doi: 10.1126/science.151.3706.89.

Uncoupling of an epithelial cell membrane junction by calcium-ion removal

M Nakas, S Higashino, W R Loewenstein

Uncoupling of an epithelial cell membrane junction by calcium-ion removal

M Nakas et al. Science. .

Abstract

Calcium takes part in maintaining ion communication between salivary gland cells (Chironomus thummi). Its withdrawal from the cell systems results in virtual disconnection of ion communication, at Ca(++) concentrations which do not noticeably affect cell adhesion. The junctional membrane surfaces. which are normally quite freely permeable to ions, become as impermeable as the nonjunctional membrane surfaces; each cell seals itself off irreversibly as a unit. In maintaining ion communication Mg(++) substitutes for Ca(++)

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