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. 1967 Apr;93(4):1374-81.
doi: 10.1128/jb.93.4.1374-1381.1967.

Autolysis and secondary growth of Mycobacterium tuberculosis in submerged culture

L G Wayne, G A Diaz

Autolysis and secondary growth of Mycobacterium tuberculosis in submerged culture

L G Wayne et al. J Bacteriol. 1967 Apr.

Abstract

Mycobacterium tuberculosis has been found to exhibit autolysis and spontaneous secondary growth in modified Sauton medium. The phenomenon is a function of high glycerol concentration of the medium and limitation of air in test tubes. It is not a function of depletion of nutrients and is probably not a manifestation of lysogeny or spheroplast formation. The cycle of growth, autolysis, and secondary growth is related to development of lethal conditions during a period of severe oxygen limitation followed by a metabolic change associated with slower depletion of glycerol.

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References

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