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. 1967 Oct;94(4):815-20.
doi: 10.1128/jb.94.4.815-820.1967.

Kinetics and immunoglobulin nature of the antibody response to Mycobacterium tuberculosis

J E O'Connor, I S Snyder

Kinetics and immunoglobulin nature of the antibody response to Mycobacterium tuberculosis

J E O'Connor et al. J Bacteriol. 1967 Oct.

Abstract

Antibody production after injection of Mycobacterium tuberculosis was studied by use of the single cell plaque assay technique. Maximal numbers of antibody-forming cells were found 9 days after a single injection of M. tuberculosis, about 1 day before the appearance of maximal circulating antibody. Immunoelectrophoretic studies and 2-ME studies on 19S and 7S globulin fractions obtained by gel filtration show that the hemagglutination and hemagglutination-lysis antibody activity is associated with 19S immunoglobulin.

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